PDXリスト
PDX資源のご利用をご検討の方は、ご利用機関と医薬基盤研究所の共同研究契約、ならびに第三者への委託契約を行うとともに、研究倫理委員会の承諾が必要になります。
ご利用条件
① 共同研究契約における契約内容を遵守すること
② PDX資源のウイルス検査、臨床・病理検査、標的、経過、薬剤耐性等の詳細情報は、契約の意図を確認の上で提供されること
③ レシピエントマウスは特に記載がない限り、スーパーSCIDマウス（詳細は構築中）であること
④ 前立腺がんとGISTに関しては、論文発表まで、学術的共同研究を最優先すること
詳細に関してはお問合せ下さい。
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既知突然変異に関しては
突然変異率＞98％で遺伝子名を記載
突然変異率＞50％で（遺伝子名）記載
| 頭頚部腫瘍 Top | |||||||
|---|---|---|---|---|---|---|---|
| PDX. No | 臨床診断 | 病理組織診断 | 特徴 | 既知突然変異 | 手術・移植日 | 性 | 年齢 |
| NOp.528 | 甲状腺がん | Anaplastic adenocarcinoma | 再発気管食道浸潤 | KDR , TP53 , (BRAF , PIK3CA) | 2010-11-04 | M | 75 |
| NOp.780 | 甲状腺がん(右） | Papillary adenocarcinoma | 2012-05-10 | F | 49 | ||
| NOp.1312 | 甲状腺がん（左） | Papillary adenocarcinoma | 2016-02-01 | M | 51 | ||
| NOp.1575 | 甲状腺がん（右） | Papillary adenocarcinoma | 2017-03-27 | F | 47 | ||
| NOp.1657 | 甲状腺がん（右） | Papillary adenocarcinoma | 2017-09-11 | M | 79 | ||
| 食道・胃腫瘍 Top | |||||||
| PDX. No | 臨床診断 | 病理組織診断 | 特徴 | 既知突然変異 | 手術・移植日 | 性 | 年齢 |
| NOp.611 | 食道がん | Squamous cell carcinoma, moderately differentiated type | なし | 2011-05-17 | M | 69 | |
| NOp.668 | 食道胃接合部がん | Signet-ring cell carcinoma ：Poorly differentiated adenocaricnoma | なし | 2011-09-21 | F | 77 | |
| NOp.787 | 下部食道がん | Squamous cell carcinoma, moderately differentiated type | なし | 2012-05-22 | M | 46 | |
| NOp.840 | 食道がん | Squamous cell carcinoma, moderately differentiated | 頸部LN転移、化療後 | 2012-10-02 | M | 69 | |
| NOp.893 | 食道がん | Carcinosarcoma | SCC治療後がん肉腫 | 2013-04-08 | M | 58 | |
| NOs.1307 | 食道がん | Squamous cell carcinoma, moderately differentiated | 2016-02-01 | F | 63 | ||
| NOs.1308 | 食道がん | Squamous cell carcinoma, moderately differentiated | 2016-02-01 | M | 80 | ||
| NOｓ1309 | 食道がん | Squamous cell carcinoma, moderately differentiated | 2016-02-01 | M | 62 | ||
| NOs.1342 (1438) | 食道がん | Squamous cell carcinoma, moderately differentiated | 2016-03-28 | F | 52 | ||
| NOs.1437 | 食道がん | Squamous cell carcinoma, well-moderately differentiated | 2016-08-19 | M | 74 | ||
| NOp.434 | 胃がん | Tubular adenocarcinoma, moderately differentiated type | スキルス | なし | 2010-05-13 | M | 69 |
| NOp.518 | 胃がん | Tubular adenocarcinoma, moderately differentiated type | S1 1年間投与 | P53 (KIT) | 2010-10-21 | M | 78 |
| NOp.527 | 胃がん | Tubular adenocarcinoma, moderately differentiated type | なし | 2010-11-01 | M | 68 | |
| NOp.857 | 幽門前庭部がん | Moderately differentiated tubular adenocarcinoma | 肝転移あり、化学療法後１a 幽門狭窄 | KDR | 2012-12-10 | M | 66 |
| NOp.861 | 胃がん | Tubular adenocarcinoma, moderately differentiated | 2012-12-27 | M | 68 | ||
| NOp.925 | 胃がん | Moderately differentiated tubular adenocarcinoma | 2013-06-12 | F | 68 | ||
| NOp.953 | 胃がん | Triple cancer; adenocarcinoma a)por1b) tub1, c) tub2 2) Metastatic adenocarcinoma i | 3腫瘍に連続性なし | 2013-08-13 | M | 77 | |
| NOp.1012 | 胃がん | Adenocarcinoma | スキルス | 2013-12-26 | F | 39 | |
| NOp.1522 | 食道胃接合部がん | Tubular adenocarcinoma, | 2017-01-05 | M | 71 | ||
| NOp.1564 | 胃がん | Adenocarcinoma | スキルス | 2017-03-07 | F | 49 | |
| NOp.1241-1 | 右転移性肺腫瘍 | Metastatic carcinoma、TTF-1(-), NapsinA(-), CDX-2(+), HNF-4a(+) | 胃癌肺転移 | TTF-1(-), NapsinA(-), CDX-2(+), HNF-4a(+) | 2015-07-30 | M | 46 |
| 大腸腫瘍 Top | |||||||
| PDX. No | 臨床診断 | 病理組織診断 | 特徴 | 既知突然変異 | 手術・移植日 | 性 | 年齢 |
| NOp474 | 結腸がん（S） | Tubular adenocarcinoma, moderately differentiated | なし | 2010-07-29 | F | 74 | |
| NOp.478 | 結腸がん（Ａ） | Well differentiated tubular adenocarcinoma | 肝転移、脾臓転移、化療＋ | SMAD4 （APC , KRAS , STK11 , PIK3CA） | 2010-08-10 | M | 63 |
| NOp.486 | 直腸がん(Rb) | Tubular adenocarcinoma, moderately differentiated | 胆管細胞がん既往有 | なし | 2010-09-02 | M | 80 |
| NOp.499 | 直腸がん(Ra) | Tubular adenocarcinoma, moderately differentiated | 術後Adjuvant chemo. | KRAS | 2010-09-27 | M | 64 |
| NOp.513 | 直腸がん(Rs) | Moderately differentiated tubular adenocarcinoma | KRAS | 2010-10-14 | M | 68 | |
| NOp.515 | 直腸がん(Ra) | Tubular adenocarcinoma, moderately differentiated | PIK3CA | 2010-10-18 | M | 60 | |
| NOp.526 | 直腸がん（Rs) | Tubular adenocarcinoma, well differentiated | KRAS | 2010-11-01 | M | 67 | |
| NOp.538 | 直腸がん（Ra） | Tubular adenocarcinoma, moderately differentiated | なし | 2010-11-18 | M | 69 | |
| NOp.1027-1 | 右再発性転移性肺腫瘍 | Metastatic adenocarcinoma | 大腸癌（粘液癌） 肺転移 | AKT1, （KRAS , KDR） | 2014-02-10 | F | 73 |
| NOp.1051-1 | 左転移性肺腫瘍 | Metastasis of rectal adenocarcinoma ,Moderately differentiated tubular adenocarcinoma of the colon | 直腸癌術後肺転移 | 2014-04-21 | M | 76 | |
| NOp.1061 | 左転移性肺腫瘍 | Metastasis of rectal cancer, | 2014.1.6直腸がん手術（Adenocarcinoma）後肺転移 | TP53 （KRAS） | 2014-05-22 | M | 71 |
| NOp.1060 | 左転移性肺腫瘍 | Metastasis of colonic cancer, | S状結腸癌肺転移 | 2014-05-22 | M | 72 | |
| NOp.1072-1 | 右転移性肺腫瘍 | Metastasis of rectal carcinoma | 大腸癌の肺転移 2013/6/4 :Moderately differentiated tubular adenocarcinoma of the colon | KDR、TP53 （KRAS, ATM) | 2014-07-03 | M | 70 |
| NOp.1093-1 | 右転移性肺腫瘍 | Metastasis of rectal adenocarcinoma | 2013/2/1 直腸がん手術 EGFR免疫染色陽性 | 2014-07-28 | F | 74 | |
| NOp.1105-1 | 左転移性肺腫瘍 | Metastasis of rectal adenocarcinoma . | 2012/1/10直腸がんTubular adenocarcinoma, moderately differentiated EGFR免疫染色陽性 | 2014-09-11 | F | 74 | |
| NOp.1106-1 | 右転移性肺腫瘍 | Metastatic carcinoma, | 2008/12/17大腸がんTubular adenocarcinoma, well differentiated | 2014-09-18 | F | 71 | |
| NOp.1112-1 | 左転移性肺腫瘍 | Metastasis of adenocarcinoma | 大腸癌肺転移 | 2014-10-16 | F | 80 | |
| NOp.1184-1 | 左転移性肺腫瘍 | Metastatsis of rectal adenocarcinoma | 直腸癌術後 | 2015-03-09 | F | 80 | |
| NOp.1189-1 | 左転移性肺腫瘍 | Metastasis of rectal carcinoma, | 直腸癌肺転移 2014.3.12直腸がんAdenocarcinoma | 2015-03-23 | M | 67 | |
| NOp.1208-1 | 右転移性肺腫瘍 | Metastasis of colonic adenocarcinoma | 他院大腸癌術後 | 2015-04-16 | M | 67 | |
| NOp.1292-1 | 左転移性肺腫瘍 | Mestasis of colon cance | 大腸がん肺転移（NOｐ１１０６と同一患者） | 2016-01-14 | F | 72 | |
| NOp.1300-1 | 右転移性肺腫瘍 | Metastatic carcinoma, | 直腸がん術後 | 2016-01-25 | M | 80 | |
| NOp.1475-1 | 右転移性肺腫瘍 | Metastastic adenocarcinoma | 2014.8.6大腸がんModerately differentiated tubular adenocarcinoma of the colon | 2016-10-06 | F | 54 | |
| NOp.1525-1 | 左転移性肺腫瘍 | Metastatic cancer, colon origin | 2016.2.15 結腸がんMalignancy Metastatic adenocarcinoma | 2017-01-12 | F | 61 | |
| NOp.1203 | 転移性肝腫瘍 | Metastatic colonic adenocarcinoma | 大腸癌転移、(胃SMT) | 2015-04-06 | F | 67 | |
| NOp.1644 | 転移性肝腫瘍 (S8) | Metastatic carcinoma, compatible with metastasis of colon cancer | 大腸がん肝転移、腎癌手術暦有 | 2017-09-04 | M | 54 | |
| NOp.1713 | 転移性肝腫瘍（Ｓ４，５） | Metastatic colonic adenocarcinoma | S状結腸癌肝転移 | 2018-02-01 | M | 62 | |
| NOp.1719 | 転移性肝腫瘍（３ヶ所） | Metastatic colonic adenocarcinoma | S状結腸癌肝転移 | 2018-02-22 | F | 77 | |
| NOp.1728 | 転移性肝腫瘍（2か所） | Metastatic colonic adenocarcinoma | S状結腸癌肝転移 | 2018-03-12 | M | 58 | |
| 膵臓腫瘍 Top | |||||||
| PDX. No | 臨床診断 | 病理組織診断 | 特徴 | 既知突然変異 | 手術・移植日 | 性 | 年齢 |
| NOpOs.175 | 膵がん肝転移 | Ductal adenocarcinoma | (TP53, KRAS, STK11) | 1991-12-16 | M | 28 | |
| NOpOs.191 | 十二指腸乳頭がん | T3 Poorly differentiated adenocarcinioma | ＣＥＡ(-), CA19-9(-) LN 転移(+) | なし | 1992-03-05 | Ｆ | 67 |
| NOp.479 | 膵がん胃浸潤 | Disseminated adenocarcinoma to peritonium | 腸間膜播腫部摘出 | なし | 2010-08-17 | F | 69 |
| NOp.539 | 膵がん（体部） | Invasive ductal carcinomas | KRAS p53 | 2010-11-18 | F | 74 | |
| NOp.563 | 十二指腸乳頭がん | Tubular adenocarcinoma, well differentiated | PIK3CA, FGFR2, (KDR , KIT) | 2011-01-02 | Ｆ | 61 | |
| NOp.565 | 膵がん | Tubular adenocarcinoma, moderately differentiated with foci of squamous cell carcinoma | 術後化療＋ | TP53 (KRAS) | 2011-01-25 | Ｆ | 74 |
| NOp.577 | 膵頭部がん | Tubular adenocarcinoma, well differentiated | 胃がん胃全摘後 | (STK11) | 2011-02-17 | F | 62 |
| NOp.593 | 膵頭部がん | Tubular adenocarcinoma, moderately differentiated | 術後化療＋ | KRAS | 2011-03-17 | M | 67 |
| NOp.645 | 膵頭部がん | Invasive ductal carcinoma, ; Tubular adenocarcinoma , moderately differentiated | 術後化療＋ | KRAS | 2011-08-11 | F | 63 |
| NOp.661 | 膵がん | Tubular adenocarcinoma, moderately differentiated | 術後化療＋ | KDR, KRAS , TP53 (APC) | 2011-09-06 | F | 83 |
| NOp.722 | 膵内分泌がん（PNET） 、肝転移 | Neuroendocrine carcinoma, large cell type | 肝転移有、術前後化療 | なし | 2012-01-24 | M | 65 |
| NOp.1146 | 下部胆管がん（膵頭部腫瘍） | Adenocarcinoma | 2014-12-25 | F | 74 | ||
| NOp.1276 | 膵体部ＩＰＭＣ | Intraductal papillary-mucinous carcinoma, invasive | 2015-09-03 | F | 63 | ||
| NOp.1318 | 膵頭部がん | Invasive ductal carcinoma, moderately differentiated type | 2016-02-12 | M | 58 | ||
| NOp.1333 | 膵頭部がん | Invasive ductal carcinoma, tubular adenocarcinoma, moderately differentiated type | 2016-03-10 | M | 80 | ||
| NOp.1510 | 膵がん（膵体部移行部） | Invasive ductal carcinoma, mod>wel, | 2016-12-12 | F | 70 | ||
| NOp.1609 | 膵がん | Invasive ductal carcinoma | 副腎合併切除 | 2017-06-19 | F | 55 | |
| NOp.1665 | 膵頭部がん | Invasive ductal carcinoma, | 2017-09-19 | M | 57 | ||
| NOp.1666 | 膵体尾部がん | Invasive ductal carcinoma, adenocarcinoma, moderately differentiated, | 2017-09-21 | M | 64 | ||
| NOp.1671 | Vater乳頭がん | Tubular adenocarcinoma, | 2017-10-10 | M | 75 | ||
| 肝・胆管腫瘍 Top | |||||||
| PDX. No | 臨床診断 | 病理組織診断 | 特徴 | 既知突然変異 | 手術・移植日 | 性 | 年齢 |
| NOp.531 | 肝細胞がん | Hepatocellular carcinoma, double lesion (moderate, well differentiated) | nonB nonC マウス内転移 | なし | 2010-11-09 | M | 71 |
| NOp.639 | 肝細胞がん | Moderately differentiated hepatocellular carcinoma, | nonBnonC 重複癌(胃癌全摘、肝S8亜区域切除） | なし | 2011-07-26 | M | 81 |
| NOp.898 | 肝細胞がん | Moderately differentiated hepatocellular carcinoma | nonBnonC | 2013-04-30 | F | 43 | |
| NOp.1022 | 中下部胆管がん | Adenocarcinoma; | 2014-01-30 | M | 54 | ||
| NOp.1103 | 胆のうがん | Adenocarcinoma, | 2014-08-28 | M | 74 | ||
| NOp.1198 | 下部胆管がん | Adenocarcinoma , | 2015-03-30 | M | 84 | ||
| NOp.1234 | 下部胆管がん | Adenocarcinoma, | 2015-06-29 | M | 68 | ||
| NOp.1280 | 肝内胆管がん（S5/8) | Intrahepatic cholangiocarcionma, moderate to poorly differentiated adenocarcinoma | nonBnonC 免疫染色で肝細胞(-), Arginase(-), Glypican3(-), CK19(+)AlcianBlue陽性の粘液 | 2015-09-17 | M | 73 | |
| NOp.1337 | 肝濾胞性リンパ腫（Ｓ3､Ｓ6/７） | Follicular lymphoma （malignancy) | nonBnnC | 2016-03-18 | F | 84 | |
| NOp.1389 | 転移性肝腫瘍 | Extraadrenal paraganglioma, metastatic ---liver | パラガングリオーマの肝転移 | 2016-06-09 | M | 58 | |
| NOp.1595 | 肝細胞がん（Combind type) | Combined hepatocellular and cholangiocarcinoma | nonBnonC | 2017-05-08 | M | 63 | |
| NOp.1618 | 肝内胆管がん 肝転移 | Recurrence of intrahepatic cholangiocarcinoma, | 2017-07-03 | F | 78 | ||
| NOp.1620 | 肝内胆管がん(S8/4） | Intrahepatic chorangiocarcinoma, | 2017-07-13 | F | 80 | ||
| NOp.1664 | 肝細胞がん（S4、8） | Combined hepatocellular and cholangiocarcinoma | nonBnonC .免疫染色にて①肝細胞がんCK7(-)、CK19(-)、Hepatocyte(+)、Arginase-1(+) ②胆管がんCK7(+)、CK19(+)、Hepatocyte(-)、 | 2017-09-14 | M | 72 | |
| NOp.1678 | 肝がん（S8） | Metastatic carcinoma, breast origin | この症例はtriple negative乳癌の肝転移 | 2017-11-02 | F | 59 | |
| NOp.1729 | 下部胆管がん | Invasive ductal carcinoma, adenocarcinoma, well differentiated | 膵切除 | 2018-03-15 | M | 57 | |
| 肺腫瘍 Top | |||||||
| PDX. No | 臨床診断 | 病理組織診断 | 特徴 | 既知突然変異 | 手術・移植日 | 性 | 年齢 |
| NOp.490-1 | 右肺がん | Adenocarcinoma with mixed subtypes (AC+BAC+pap) (BAC 20%) | EGFR遺伝子変異無し | (EGFR, TP53) | 2010-09-06 | F | 63 |
| NOp.522-1 | 肺がん | Squamous cell carcinoma, moderately differentited | なし | 2010-10-28 | M | 74 | |
| NOp.552-1 | 肺がん | Adenocarcinoma with mixed subtypes (BAC+AC) (BAC 90%) | 前立腺癌 2010/9/1 prostate. biopsy ： Well differentiated adenocarcinoma, Gleason score 6= 3+3 | なし | 2011-01-06 | M | 65 |
| NOp.554-1 | 右肺がん | Adenocarcinoma with mixed subtypes(BAC＋solid+acinar) | 野口分類typeD | 2011-01-06 | F | 45 | |
| NOp.575-1 | 左肺がん | Carcinosarcoma (Chondrosarcoma + Adenocarcinoma) | TP53, STK11 (NRAS , MET) | 2011-02-14 | M | 75 | |
| NOp.590-1 | 右肺がん | Squamous cell carcinoma, moderately differentiated | なし | 2011-03-17 | M | 86 | |
| NOp.604-1 | 右上肺がん | Squamous cell carcinoma, moderate-well differentited | なし | 2011-04-11 | M | 62 | |
| NOp.618-1 | 左上肺がん | Bronchioloalveolar caricinoma, non-mucinous type, Noguchi B type | 野口分類typeB 乳がん再発病変あり | なし | 2011-06-16 | F | 84 |
| NOp.624-1 | 左肺がん | Malignancy Metastatic thymoma type B3 in lung | 未分化癌（悪性度高い） | なし | 2011-06-23 | F | 82 |
| NOp.637-1 | 左下肺がん | Adenocarcinoma with mixed subtypes (acinar+pap+BAC) (BAC 10%) | EGFR | 2011-07-11 | M | 65 | |
| NOp.662-1 | 右上肺がん | Squamous cell carcinoma, well differentiated | CDKN2A/TP53 FBXW7 | 2011-09-08 | M | 75 | |
| NOp.666-1 | 左下肺がん | Pleomorphic carcinoma | TP53 | 2011-09-15 | M | 74 | |
| NOp.681-1 | 肺がん | Squamous cell carcinoma | 下咽頭癌の術後(転移性の可能性高） | なし | 2011-11-10 | M | 63 |
| NOp.682-1 | 右上葉肺がん | Poorly differentiated squamous cell carcinoma | TTF-1(-), Napsin A(-), p63(+), CK14(-) | なし | 2011-11-10 | M | 79 |
| NOp.697-1 | 右下肺がん | Squamous cell carcinoma、moderately differentiated | なし | 2011-12-08 | M | 73 | |
| NOp.707-1 | 右上肺がん | Adenocarcinoma with mixed subtype (Solid+AC), poorly differentiated | なし | 2011-12-26 | M | 70 | |
| NOp.720-1 | 右上肺がん | Adenocarcinoma with mixed subtype (BAC+pap) (BAC 70%) | (EGFR, TP53) | 2012-01-19 | F | 63 | |
| NOp.755-1 | 右下葉肺がん | Poorly differentiated squamous cell carcinoma, | SqCC（p63+CK14）陽性、ADC（TTF-1+NaspinA）陰性、Chromogranin陰性、Synaptophysin陰性、ALK陰性 | 2012-03-26 | M | 74 | |
| NOp.790-1 | 左上肺がん | Bronchioloalveolar carcinoma, mucinous type | ALK(-) | なし | 2012-05-31 | F | 70 |
| NOp.819-1 | 右上葉肺がん | Adenocarcinoma with mixed subtype (BAC+pap) (BAC 90%) | なし | 2012-08-09 | M | 68 | |
| NOp.862-1 | 右下葉肺がん | Squamous cell carcinoma, moderately differentiated differentiated | なし | 2013-01-10 | M | 78 | |
| NOp.875-1 | 左上葉肺がん | Squamous cell carcinoma, moderately differentiated differentiated | なし | 2013-02-14 | M | 70 | |
| NOp.890 | 左下葉肺がん | Squamous cell carcinoma, | TTF-1(-), p40(ΔNp63)(+), ALK(-) | 2013-03-25 | M | 73 | |
| NOp.907 | 右中葉肺がん | Squamous cell carcinoma, moderately differentiated differentiated | なし | 2013-05-16 | M | 73 | |
| NOp.910 | 右下葉肺がん | Adenocarcinoma, mixed subtype (acinar > BAC) | 2013-05-20 | M | 72 | ||
| NOp.914 | 右下葉肺がん | Adenocarcinoma, with mixed subtype (papillary >>acinar type), | なし | 2013-05-27 | F | 65 | |
| NOp.920 | 左下葉肺がん | Squamous cell carcinoma, moderately differentiated differentiated | KRAS, TP53 | 2013-06-06 | M | 80 | |
| NOp.929 | 右上葉肺がん | Squamous cell carcinoma, well differentiated | なし | 2013-06-20 | M | 64 | |
| NOp.934 | 左下葉肺がん | Squamous cell carcinoma, well differentiated | なし | 2013-06-27 | M | 56 | |
| NOp.951 | 右中葉肺がんの疑い | Metastaic carcinoma, | 子宮内膜癌の転移 p53(-), p16(+), ER(少数に弱+), PgR(-) 2010/7/20 Serous adenocarcinoma | 2013-08-12 | F | 58 | |
| NOp.954 | 右下葉肺がん | Squamous cell carcinoma, moderately differentiated | 2013-08-19 | M | 72 | ||
| NOp.959 | 右下葉肺がん | Squamous cell carcinoma, well differentiated, papillary type | なし | 2013-08-29 | M | 61 | |
| NOp.975 | 右下葉肺がん | Squamous cell carcinoma, moderately differentiated | なし | 2013-10-07 | M | 76 | |
| NOp.980 | 右上葉肺がん | Squamous cell carcinoma | なし | 2013-10-24 | M | 80 | |
| NOp.1002-1 | 右下葉肺がん | Squamous cell carcinoma, | 2013-12-02 | M | 72 | ||
| NOp.1016-1 | 左上葉肺がん | Squamous cell carcinoma, well differentiated | 2014-01-16 | M | 77 | ||
| NOp.1058 | 右上葉肺がん | Squamous cell carcinoma | 2014-05-19 | M | 66 | ||
| NOp.1067-1 | 左下葉肺がん | Squamous cell carcinoma, | なし | 2014-06-09 | M | 68 | |
| NOp.1068-1 | 左下葉肺がん | Squamous cell carcinoma, poorly differentiated | p40(+), TTF-1(-) | 2014-06-16 | M | 72 | |
| NOp.1069-1 | 左下葉肺がん | Adenosquamous carcinoma, | HNF4α陽性 | 2014-06-16 | M | 70 | |
| NOp.1095-1 | 左上葉肺がん | Adenocarcinoma, mixed subtype (lepidic > papillary > acinar) | 2014-07-31 | F | 73 | ||
| NOp.1109-1 | 左上葉肺がん | Squamous cell carcinoma, poorly differentiated | 2014-10-06 | M | 65 | ||
| NOp.1111-1 | 右上葉肺がん | Squamous cell carcinoma, TTF-1(-), Napsin A(-), p40(+), CK14(-), ALK(-) | 2014-10-16 | M | 85 | ||
| NOp.1124-1 | 右下葉肺がん | Adenocarcinoma with mixed subtypes (pap > lepidic > acinar) | 2014-11-13 | M | 74 | ||
| NOp.1141-1 | 右上葉肺がん | Adenocarcinoma, with mixed subtype (papillary >> BAC), | EGFREx21変異特異的免疫染色陽性 | 2014-12-08 | F | 64 | |
| NOp.1145-1 | 右下葉肺がん | Adenocarcinoma with mixed subtypes (AC+pap+BAC) | EGFREx21変異特異的免疫染色；陽性 | 2014-12-25 | M | 68 | |
| NOp.1168-1 | 右上葉肺がん | Adenocarcinoma、papillary type | 2015-01-29 | M | 72 | ||
| NOp.1171-1 | 左上葉肺がん | Squamous cell carcinoma, | 2015-02-02 | M | 70 | ||
| NOp.1178-1 | 右上葉肺がん | Adenocarcinoma, acinar type, | 2015-02-09 | F | 73 | ||
| NOp.1179-1 | 左上葉肺がん | Squamous cell carcinoma | 2015-02-12 | M | 74 | ||
| NOp.1194-1 | 右下葉肺がん | Bronchioloalveolar carcinoma, non-mucinous type | 2016-11-05 | F | 74 | ||
| NOp.1228-1 | 左下葉肺がん | Adenocarcinoma, with mixed subtype (lepidic > papillary), | EGFREx21変異特異的免疫染色；陽性 | 2015-06-01 | F | 80 | |
| NOp.1232-1 | 左上葉肺がん | Squamous cell carcinoma with foci of adenocarcinoma component, | P40陽性、CK14陰性、TTF-1陰性、NapsinA、ALK陰性 | 2015-06-29 | M | 75 | |
| NOp.1233-1 | 右上葉肺がん | Adenocarcinoma, with mixed subtype (lepidic >> acinar > papillary), | EGFREx21変異特異的免疫染色；陽性 マウス遠隔転移 | 2015-06-29 | M | 73 | |
| NOp.1266-1 | 右上葉肺がん | Adenocarcinoma, with mixed subtype (solid>>papillary) | 2016.8.24PSBF | 2016-11-05 | F | 80 | |
| NOp.1269-1 | 左上葉肺がん | Pleomorphic carcinoma | AE1/3陽性、vimentin陽性、p40少数陽性、CK14少数陽性、TTF-1陰性、Napsin-A陰性 | 2015-08-27 | M | 57 | |
| NOp.1305-1 | 左上葉肺がん | Adenocarcinoma, papillary type, | 2016-01-28 | M | 65 | ||
| NOp.1327-1 | 右下葉肺がん | Invasive mucinous carcinoma | 2016-03-03 | F | 65 | ||
| NOp.1386-1 | 右中葉肺がん | Large cell carcinoma, | 2016-06-06 | M | 63 | ||
| NOp.1388-1 | 肺がん | Adenocarcinoma, papillary type, | 2016-06-09 | M | 60 | ||
| NOp.1395-1 | 左下葉肺がん | Invasive adenocarcinoma, acinar predominant (acinar>papillary) | EGFREx21変異特異的免疫染色；陽性 | 2016-06-20 | M | 71 | |
| NOp.1396 | 左転移性胸膜腫瘍, 胸腺腫, | Disseminated thymoma cells; Pleura WHO type B2-B1 | 重症筋無力症, 悪性胸腺腫 | 2016-06-23 | M | 52 | |
| NOp.1401-1 | 右上葉肺がん | Squamous cell carcinoma | 2016-12-24 | M | 66 | ||
| NOp.1440-1 | 右上葉肺がん | Invasive adenocarcinoma, papillary predominant (papillary>lepidic), | 2016-08-22 | F | 83 | ||
| NOp.1443-1 | 左上葉肺がん | Invasive adenocarcinoma, lepidic predominant | EGFREx21変異特異的免疫染色；陰性 ALK免疫染色；陰性 | 2016-08-25 | F | 48 | |
| NOp.1468-1 | 右中葉肺がん | Invasive adenocarcinoma, acinar predominant (acinar>lepidic), | PAX8陰性、Thyroglobulin陰性 EGFREx21変異特異的免疫染色；陰性, ALK免疫染色；陰性 | 2016-09-26 | F | 83 | |
| NOp.1471-1 | 左上葉肺がん | Adenocarcinoma in situ, non-mucinous, | 胃粘膜内に高?中分化な腺癌の管状、乳頭状増殖を認める 2016.9.29 PSBF | 2016-10-03 | F | 73 | |
| NOp.1474-1 | 右下葉肺がん 腺がん | Adenocarcinoma, acinar pattern predominant | 2016.9.29PSBF マウス内遠隔転移 | 2016-11-05 | F | 83 | |
| NOp.1480-1 | 左上葉肺がん PSBF | Microinvasive adenocarcinoma(MIA) | 2016-12-29 | F | 73 | ||
| NOp.1491-1 | 右下葉肺がん PSBF | Squamous cell carcinoma, | 2016.10.24 PSBF | 2017-03-31 | M | 79 | |
| NOp.1504-1 | 左下葉肺がん | Adenocarcinoma, mixed subtype (papillary > lepidic), | 2016-11-17 | M | 71 | ||
| NOp.1508-1 | 右下葉肺がん | Combined small cell carcinoma (SCLC+LCNEC), | 2016-12-12 | M | 64 | ||
| NOp.1512-1 | 右上葉肺がん | Squamous cell carcinoma, | 2016-12-22 | M | 74 | ||
| NOp.1531-1 | 右上葉肺がん | Invasive adenocarcinoma, acinar predominant (acinar>lepidic), | 2017-01-16 | F | 78 | ||
| NOp.1541-1 | 左下葉肺がん | Invasive adenocarcinoma, lepidic predominant (lepidic 70%, acinar 30%) | 2017-01-30 | F | 78 | ||
| NOp.1545-1 | 左下葉肺がん | Invasive adenocarcinoma, acinar predominant (acinar: 90%, lepidic : 10%) | 2017-02-06 | F | 83 | ||
| NOp.1549-1 | 右下葉肺がん | Squamous cell carcinoma, | 2017-02-09 | F | 76 | ||
| NOp.1579-1 | 左下葉肺がん | Large cell neuroendocrine carcinoma | Synaptophysin(-), Chromogranin A(-), NCAM(少数+), TTF-1(-), p40(-) | 2017-04-10 | M | 76 | |
| NOp.1585-1 | 右上葉肺がん | Invasive adenocarcinoma, | EGFREx21変異特異的免疫染色；陰性。 ALK免疫染色陰性 | 2017-04-20 | M | 66 | |
| NOp.1625-1 | 左上葉肺がん | Adenosquamous carcinoma, | TTF-1陽性 | 2017-07-27 | M | 82 | |
| NOp.1627-1 | 右中葉肺がん | Residue of carcinoma cells | 化学療法後 | 2017-07-31 | M | 60 | |
| NOhOs788 | 胸水 | 胸水の細胞診、Class Vで肺腺癌陽性 （がん細胞はほとんど認めず） | 無治療、右胸水、EGFR（－） 胸水よりＰＤＸ樹立 | KRAS | 2012-05-23 | F | 89 |
| NOhOs796 | 胸水 | 胸水の細胞診；腺がん D1 | 胸水、EGFR(+)、ＥＧＦＲ－ＴＫＩ他各種治療済 胸水よりＰＤＸ樹立 | なし | 2012-06-15 | F | 54 |
| NOhOs818 | 胸水 | 胸水の細胞診でadnocarcinoma Class V B1 | 術後再発で右胸膜播種、両側肺内転移、右胸水よりＰＤＸ樹立 | 2012-08-02 | F | 67 | |
| NOhOs879 | 胸水 | 胸水の細胞診；Class V腺癌 | 胸水よりＰＤＸ樹立、細胞培養（＋） | 2013-02-19 | M | 67 | |
| NOhOs927 | 胸水 | 肺腺がん胸水 | 胸水よりＰＤＸ樹立 | 2013-06-14 | F | 91 | |
| NOhOs948 | 胸水 | 肺腺癌 T4N2M1a stage IV 右がん性胸膜炎＋胸膜播種 | 遠隔転移無。EGFR exon19 del 胸水よりＰＤＸ樹立 | KDR | 2013-08-05 | F | 61 |
| 乳腺腫瘍 Top | |||||||
| PDX. No | 臨床診断 | 病理組織診断 | 特徴 | 既知突然変異 | 手術・移植日 | 性 | 年齢 |
| NOp.450 | 乳がん（左） | Invasive ductal carcinoma, scirrhous carcinoma with invasive micropapillary carcinoma component,, ER+ 91.6% | アロマシン服用６ヶ月での早期再発 | ATM | 2010-06-17 | F | 68 |
| NOp.502 | 乳がん（左） | Ductal carcinoma in situ(DCIS), non-comedo type, | DCIS | なし | 2010-09-30 | F | 77 |
| NOp.516 | 乳がん（左） | Mucinous carcinoma, pure type, ER+, 96.9% | なし | 2010-10-21 | F | 88 | |
| NOp.541 | 左乳がん | Invasive ductal carcinoma, solid-tubular carcinoma ER+, 71.3% | KDR PIK3CA | 2010-11-25 | F | 87 | |
| NOp.607 | 乳がん術後局所再発 | Apocrine carcinoma; s, f, NG3, ly2, v0 ---Lt Breast | triple negative 局所再発 | 2011-04-28 | F | 46 | |
| NOp.713 | 左乳がん | Invasive ductal carcinoma, papillotubular carcinoma with foci of invasive micropapillary carcinoma, ER+ 70% | 早期局所再発、高悪性度 | なし | 2012-01-12 | F | 75 |
| NOp.850 | 乳がん（右） | Invasive ductal carcinoma, papillotubular carcinoma with foci of invasive micropapillary carcinoma ; ER+, 70%, DFI | 1.5年で早期転移、高齢のため内分泌治療のみ施行、再発後２年で永眠。高悪性度腫瘍。 | なし | 2012-11-13 | F | 82 |
| NOp.904 | 左乳がん 硬がん | Invasive ductal carcinoma, solid-tubular carcinoma, ER(+,99%) | EIC(-), post neoadjuvant chometherapy state: grade 1a | 2013-05-09 | F | 63 | |
| NOp.1107 | 乳がん（右） | Invasive ductal carcinoma, papillotubular type ER(+,99%) | リンパ節転移４個。 | 2014-09-18 | F | 51 | |
| NOp.1265 | 乳がん（右） | Invasive ductal carcinoma, papillo-tubular type, ER(-,<1%), HER2(-, score1+) | triple negative 症例。当初センチネルn0。半年後腋窩再発してn3/40 | 2015-08-12 | F | 36 | |
| NOp.1293 | 左乳がん | Invasive ductal carcinoma, solid-tubular type, ER+９９％、NG３，Ki27％6) | 2016-01-14 | F | 67 | ||
| NOp.1334 | 乳がん（右） 左も？ 浸潤性乳管がん | Invasive ductal carcinoma, scirrhous type | triple negative 症例。 | 2016-03-10 | F | 77 | |
| 腎・膀胱・腎盂尿管・副腎腫瘍 Top | |||||||
| PDX. No | 臨床診断 | 病理組織診断 | 特徴 | 既知突然変異 | 手術・移植日 | 性 | 年齢 |
| NOp.710 | 膀胱がん | Invasive urothelial carcinoma, | P53 multi | 2012-01-11 | M | 70 | |
| NOp.740 | 膀胱がん | Invasive urothelial carcinoma, high grade(30%) with squamous(50%) and gladular(20%) differentiation | (PIK3CA, KDR) | 2012-02-17 | F | 81 | |
| NOp.756 | 右腎盂がん | Invasive urothelial carcinoma, | マウス内転移＋＋ | 2012-03-26 | F | 59 | |
| NOp.767 | 右腎盂がん | Invasive urothelial carcinoma, sarcomatoid variant-Renal pelvis : | 2012-04-13 | M | 68 | ||
| NOp.771 | 膀胱がん | Invasive urothelial carcinoma, | なし | 2012-04-18 | M | 79 | |
| NOp.776 | 右腎盂がん | Invasive urothelial carcinoma, | 2012-04-25 | F | 64 | ||
| NOp.803 | 左腎がん | High grade sarcoma, AE1/3(-),Vimentin(+),S100(-),LCA(-),Chromogoranin(-),Synaptophysin(weak+?),NSE(-),EMA（-） | 2012-06-29 | M | 68 | ||
| NOp.804 | 右腎がん | Clear cell renal cell carcinoma | (KDR) | 2012-07-04 | M | 77 | |
| NOp.836 | 膀胱がん | Invasive urothelial carcinoma high grade (60%) with squamous differentiation (30%) and glandular differentiation (9%) and giant cell variant (1%), | 2012-09-21 | M | 64 | ||
| NOp.847 | 膀胱がん | Invasive urothelial carcinoma, high grade with squamous differentiation, with foci of micropapillary carcinoma component | 前立腺の一部で、5mm大の範囲に、Gleason score 3+3=6相当のadenocarcinoma有 | 2012-10-31 | M | 82 | |
| NOp.871 | 副腎腫瘍 | Metastatic adenocarcinoma cells, unknown origin, CK7(+), CK20(+), TTF-1(+/-), CDX2(-), Pax8(-), Pax2(-) | 2013-02-01 | M | 76 | ||
| NOp.905 | 右腎がん | Clear cell renal cell carcinoma, | 2013-05-10 | M | 60 | ||
| NOp.919 | 膀胱三角部膀胱がん | Invasive urothelial carcinoma, | 2013-06-03 | M | 72 | ||
| NOp.926 | 右腎がん | Clear cell renal cell carcinoma | 2013-06-12 | M | 87 | ||
| NOp.928 | 右腎腫瘍 | Clear cell renal cell carcinoma | (MLH1) | 2013-06-19 | F | 79 | |
| NOp.935 | 膀胱がん | Invasive urothelial carcinoma, high grade (89%%), with squamous differentiation (10%) + sarcomatoid variant (1%, without heterologous element)l | 2013-07-03 | M | 77 | ||
| NOp.947 | 腎がん | Clear cell renal cell carcinoma, | 2013-08-05 | M | 83 | ||
| NOp.1014 | 右腎がん | Clear cell renal cell carcinoma | 2014-01-07 | M | 68 | ||
| NOp.1050 | 膀胱頚部膀胱がん | Invasive urothelial carcinoma, high grade (50%), with glandular differentiation (20%) and giant cell variant (30%), | 2014-04-18 | M | 72 | ||
| NOp.1056 | 腎がん | Clear cell renal cell carcinoma | 2014-05-14 | M | 89 | ||
| NOp.1066 | 左腎がん | Invasive urothelial carcinoma high grade (90%) with squamous diffrentiation (10%); | 2014-06-06 | F | 82 | ||
| NOp.1182 | 腎がん | Clear cell renal cell carcinoma | 2015-02-13 | F | 83 | ||
| NOp.1207 | 右腎盂腫瘍 | Non-invasive papillary urothelial carcinoma, | 2015-04-15 | F | 63 | ||
| NOp.1211 | 腎がん | Clear cell renal cell carcinoma | 2015-04-22 | M | 71 | ||
| NOp.1264 | 左腎盂がん | Invasive urothelial carcinoma, high grade (80%) with squamous differentiation (10%) and glandular differentiation (10%), | 2015-08-12 | F | 86 | ||
| NOp.1281 | 腎がん | Clear cell renal cell carcinoma | 2015-09-30 | M | 80 | ||
| NOp.1385 | 腎盂腫瘍 | Invasive urothelial carcinoma, | 2016-06-03 | M | 68 | ||
| NOp.1615 | 腎がん | Papillary renal cell carcinoma | 2017-06-28 | M | 71 | ||
| NOp.1724 | 腎盂がん | Non-invasive papillary urothelial carcinoma, high grade | 2018-02-27 | F | 63 | ||
| NOp.1038-1 | 左転移性肺腫瘍 | Metastasis of clear cell renal cell carcinoma in the lung, | 左腎癌転移 | TP53, VHL , KDR | 2014-03-10 | M | 54 |
| NOp.1039-1 | 左転移性肺腫瘍 | Metastatic clear cell renal cell carcinoma in the lung, | 右腎癌転移 | 2014-03-10 | M | 65 | |
| NOp.1173-1 | 左転移性肺腫瘍 | Metastasis of clear cell renal cell carcinoma, | 腎癌転移 | 2015-02-06 | M | 66 | |
| 前立腺、精巣腫瘍 Top | |||||||
| PDX. No | 臨床診断 | 病理組織診断 | 特徴 | 既知突然変異 | 手術・移植日 | 性 | 年齢 |
| NOs.415 | 前立腺がん | Poorly differentiated adenocarcinoma, Gleason score 5+5=10, | 化療、放射線照射後睾丸腫大、摘出（embryonl ca)。睾丸転移症例、未治療 PDX; PSA++ | (MET;48%) PDX: (PDGFRA-del, TP53del, MET 44.5%) | 2009-07-31 | M | |
| NOs.688 | 前立腺がん | Moderately differentiated adenocarcinoma, Gleason score? | PSA35.9, ホルモン療法後、ホルモン抵抗性となる | (PDGFRA) | 2011-11-21 | M | 84 |
| NOs.750 | 前立腺がん | Poorly differentiated adenocarcinoma, Gleason score 5+4=9 | PSA16.8、ホルモン療法後、ホルモン非依存性となる | STK11、 PDX； ＫＤＲ,ＴＰ53 | 2012-03-19 | M | |
| NOp.1282 | 前立腺がん | Adenocarcinoma, Gleason score 5+5=10, | 2015-09-30 | M | 78 | ||
| NOp.1478 | 前立腺がん、 | Adenocarcinoma, Gleason score 4～5 | 去勢抵抗性 | 2016-10-11 | M | 83 | |
| NOp.1567 | 前立腺がん | Residue of adenocarcinoma, Gleason score 5+4=9 | 去勢抵抗性 | 2017-03-08 | M | 75 | |
| NOp.1429 | セミノーマ(右） | Seminoma, | 2016-08-05 | M | 47 | ||
| 卵巣・子宮 Top | |||||||
| PDX. No | 臨床診断 | 病理組織診断 | 特徴 | 既知突然変異 | 手術・移植日 | 性 | 年齢 |
| NOs.202 | 卵巣がん | Serous adenocarcinoma | (TP53, STK) | 1992-05-12 | F | 50 | |
| NOｓ.1185 | 卵巣がん | Serous adenocarcinoma, Grade 3 | KDR (HRAS) | 2015-03-12 | F | 61 | |
| NOs.1227 | 卵巣がん | Serous adenocarcinoma, Grade 2 | 2015-05-19 | F | |||
| NOs.1442 | 卵巣がん | serous adenocarcinoma (peritoneum) | 2016-08-25 | F | 76 | ||
| GIST Top | |||||||
| PDX. No | 臨床診断 | 病理組織診断 | 特徴 | 既知突然変異 | 手術・移植日 | 性 | 年齢 |
| NOp.544 | GIST肝転移 | Metastatic gastrointestinal stromal tumor of the liver, c-kit(+)、CD34(+)、S100(-)、SMA(-)、Ｄｅｓｍｉｎ(-)、DOG-1(+) | 胃原発, , グリベック11月26日から中止 | 2010-11-30 | M | 53 | |
| NOp.664 | GIST肝転移 | Metastatic gastrointestinal stromal tumor, c-kit (+), DOG-1 (+), AE1/3(-), SMA(-), S-100(-) | 胃原発, グリベック9/9～中止 | 2011-09-13 | F | 70 | |
| NOp.738 | 小腸GIST | Peritoneal dissemination of gastrointestinal stromal tumor, c-kit (+)、CD34(-)、DOG1 (+)、S100(-)、SMA(-) | 腹膜播腫 | 2012-02-16 | M | 68 | |
| NOp.752 | 小腸GIST再発、肝転移 | Gastrointestinal stromal tumor, c-kit(+), CD34(+), DOG-1(+), SMA(-), Desmin(-), S100(-) | 回盲部腫瘤切除、消化管出血, Post Chemotherapy | KDR (48.9%,） | 2012-03-22 | M | 42 |
| NOp.782 | 胃GIST腹膜播腫 | Gastrointestinal stromal tumor, c-kit(+), DOG-1(+), SMA(-), S100(-） | ｲﾏﾁﾆﾌﾞ耐性 ｸﾞﾘﾍﾞｯｸ4/19～中止 GIST 2010.7.20胃GIST手術(c-kit(+), CD34(+), Desmin(-), SMA(-), S100(+) )、2012.5 | 2012-05-10 | M | 65 | |
| NOp.806 | 胃GIST+小網腫瘍 | Gastrointestinal stromal tumor , c-kit(+), CD34(+), DOG-1(+), SMA(-), Desmin(-), S100(-), | ｸﾞﾘﾍﾞｯｸ6月11日から中止中 | 2012-07-10 | F | 79 | |
| NOp.855 | 小腸GIST | Gastrointestinal stromal tumor, c-kit(+), DOG-1(+), SMA(+, focal), S100(focal+), | 6/5～ネオアジュバント。グリベック11/30～止 | 2012-12-06 | M | 47 | |
| NOp.874 | GIST | Gastrointestinal stromal tumor, liver, c-kit(+), DOG-1(+), SMA(-), S100(-) | イマチニブ耐性, 肝転移 | 2013-02-05 | F | 66 | |
| NOp.1001-1 | 胃GIST、腹膜播種 | Gastrointestinal stromal tumor、c-kit(+), CD34(+, focal), DOG-1(+), SMA(+, focal), Desmin(-), S100(-)、Post Chemotherapy | ﾈｵｱｼﾞｭﾊﾞﾝﾄ途中で、間質性肺炎後、胃，, | KIT (68.4%）, PIK3CA (51.2%） | 2013-11-27 | M | 69 |
| NOp.1074 | 回腸GIST | Gastrointestinal stromal tumor, DOG-1(+), c-kit(+), CD34(-), SMA(-、少数ながら陽性細胞+), Desmin(-), S100(-) | 2014-07-11 | M | 67 | ||
| NOp.1091 | 胃体上部ＧＩＳＴ | Gastrointestinal stromal tumor, c-kit(+)、DOG-1(+)、CD34(+)、desmin(-)、SMA(-)性、S-100(-) | ﾌﾟﾗﾋﾞｯｸｽ 7/18～止 | 2014-07-25 | F | 77 | |
| NOp.1114 | 胃GIST再発 | Gastrointestinal stromal tumor, c-kit(+), DOG-1(+), CD34(+), SMA(-), S100(-), Desmin(-) | ｸﾞﾘﾍﾞｯｸ10/10～止 | 2014-10-17 | M | 74 | |
| NOp.1137 | 胃巨大GIST | Gastrointestinal stromal tumor, chemotherapy: grade 2 c-kit(+), DOG-1(+), CD34(+), SMA(-), S100(-), Desmin(-) | 胃部切、脾摘、間質性肺炎ありｸﾞﾘﾍﾞｯｸ中止中 post neoadjuvant chemotherapy | 2014-11-27 | F | 76 | |
| NOp.1338-1 | 胃ＧＩＳＴ播種再発、 | Recurrence of gastrointestinal stromal tumor, c-kit(+)、DOG-1(+)、CD34(+)、SMA (ptialy +)、desmin (ptialy +)、S-100 (ptialy +) | NOp544と同一患者、再発例。 回盲部腫瘍切除、消化管出血 | 2016-03-22 | M | 58 | |